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Formulation:Sterile-filteredcolorlesssolution(1mg/ml)in20mMTris-HCl,pH8.0,and10%glycerol.Purifiedbyproprietarychromatographictechniques.

SERPINH1isamemberoftheserpinsuperfamilyofserineproteinaseinhibitorswhoseexpressionisinducedbyheatshock.Asamolecularchaperone,itlocalizestotheendoplasmicreticulumlumenandbindscollagen,thusparticipatinginthematurationofcollagenmolecules,facilitatingthefoldingandassemblyofprocollagenmolecules,retainingunfoldedmoleculeswithintheER,andassistinginthetransportofcorrectlyfoldedmoleculesfromtheERtotheGolgiapparatus.AutoantibodiestoSERPINH1havebeenfoundincasesofrheumatoidarthritis.

RecombinanthumanSERPINH1producedinE.coliisasingle,non-glycosylatedpolypeptidecontaining439aminoacids(aa18-417)withamolecularweightof48.9kDa.Itisfusedtoa37-aminoacidHis-tagattheN-terminus.

Source:EscherichiacoliPurity:Greaterthan90%asdeterminedbySDS-PAGE.Accessionnumber:P50454Aminoacidsequence:

RGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSHMAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL.

Storeat4oCifentirevialwillbeusedwithin2-4weeks.Storeatorbelow-20oCforlongerperiodsoftime.Additionofacarrierprotein(suchas0.1%HSAorBSA)isrecommendedforlong-termstorage.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。