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Formulation:Sterile-filteredcolorlesssolutionin20mMTris-Hcl,pH8.0,1mMEDTA,0.1MNaCl,1mMDTT,and10%

glycerol.Purifiedbyproprietarychromatographictechniques.

Hsp90β1,amemberoftheHsp90familyofmolecularchaperones,isinvolvedinmaintainingproteinhomeostasisinthesecretorypathwayandinintracellulartraffickingofpeptidesfromtheextracellularspacetotheMHCclassIantigen-processingpathwayofantigen-presentingcells.Hsp90β1haskeyrolesinsignaltransduction,proteinfolding,andproteindegradation.Itassociateswithseveralco-chaperonesinfoldingofnewlysynthesizedproteinsandrefoldingofdenaturedproteinsafterstress.Hsp90β1ishighlyexpressedinhumangastriccarcinomaBGC-823cellsthroughoutthecellcycle.

RecombinanthumanHsp90producedin

E.coliisasingle,non-glycosylatedpolypeptidecontaining819aminoacids(aa22-803)withamolecularweightof94.4kDa.Itisexpressedwitha37aminoacidHis-tagattheN-terminus.

Source:Escherichiacoli

Purity:Greaterthan90%asdeterminedbySDS-PAGEandRP-HPLC.

Accessionnumber:P14625

Aminoacidsequence:MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMDDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL.

Storeat4oCifentirevialwillbeusedwithin2-4weeks.Storeatorbelow-20oCforlongerperiodsoftime.Additionofacarrierprotein(suchas0.1%HSAorBSAisrecommendedforlong-termstorage.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

QEDBioscience,Inc.10919TechnologyPlace,SuiteC

SanDiego,CA92127

TollFree800.929.2114

Phone858.675.2405

Fax858.592.1509

info@qedbio.com

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美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。