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Formulation:Sterile-filteredsolutionin20mMTris,pH7.5,2mMEDTA,and20%glycerol.Purifiedbyproprietarychromatographictechniques.

PCNAislocatedinthenucleusandisacofactorofDNApolymerasedelta.

PCNAactsasahomotrimerandhelpsinprocessingofleADIngstrandsynthesisduringDNAreplication.InreactiontoDNAdamage,PCNAisubiquitinatedandparticipatesintheRAD6-dependentDNArepairpathway.TwotranscriptvariantsencodingthesameproteinhavebeenfoundforPCNAgene.PCNAisexpressedduringlateG1phase,Sphaseofmitosis,andpersistsuntiltheendoftheMphase.

PCNAcanbeinducedbyUVirradiation.

RecombinantHumanPCNAproducedin

E.coliisasinglenon-glycosylatedpolypeptidechaincontaining261aminoacidswithamolecularweightof28.8kDa.

Source:EscherichiacoliPurity:Greaterthan95%asdeterminedbySDS-PAGE.Accessionnumber:P12004Aminoacidsequence:

MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS.

Althoughstableat4oCfor4weeks,productisbeststoredatorbelow-20oC.Additionofacarrierprotein(suchas0.1%HSAorBSA)isrecommendedforlong-termstorage.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

QEDBioscience,Inc.10919TechnologyPlace,SuiteC

SanDiego,CA92127

TollFree800.929.2114

Phone858.675.2405

Fax858.592.1509

info@qedbio.com

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美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。