IonchannelsareintegralmembraneproteinsthathelpestablishandcontrolthesmallvoltagegrADIentacrosstheplasmamembraneoflivingcellsbyallowingtheflowofionsdowntheirelectRochemicalgradient.Clcn3mediatestheexchangeofchlorideionsagainstprotonsandfunctionsasanantiporter,contributingtotheacidificationoftheendosomeandsynapticvesiclelumen.ItmayplayanimportantroleinneuronalcellfunctionthroughregulationofmembraneexcitABIlitybyproteinkinaseC.

Thisantibodyrecognizeshuman,mouse,andratClcn3.Itdoesnotcross-reactwithClcn4orClcn5.

Immunoblotting:useat1-2ug/ml.Abandof~90kDaisdetected.

Immunohistochemistry:useat1-10ug/ml.Thesearerecommendedconcentrations.Usershoulddetermineoptimal

concentrationsfortheirapplication.

Positivecontrol:Ratbrainmembranes.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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