ORDERINGINFORMATION
CatalogNo.:12597(clone5A7-2E11)Format:100uginPBS(1mg/ml),pH7.4,50%glycerol,0.09%sodiumazide.PurifiedbyProteinGaffinitychromatography.BACKGROUND
Replicatedchromosomesincludetwokinetochoresthatcontrolchromosomesegregationduringmitosis.CentromereProtein-A(CENP-A),ahistoneH3-likeprotein,containsaC-terminalH3-likedomainwhichisrequiredforcentromerelocalizationofCENP-A.ItisessentialforkinetochoretargetingofCENP-C.InthepresenceofDNA,CENP-AformsanoctamericcomplexwithhistonesH2A,H2B,andH4.CENP-Aspecificallylocalizestoactivecentromeresandisacomponentofspecializedcentromericnucleosomesonwhichkinetochoresareassembled.
CENP-AisessentialfornucleosomalpackagingofcentromericDNAatinterphaseandfunctionsasacentromereformationMarkeronchromosomes.
SPECIFICATIONSUMMARY
Antigen:SyntheticpeptidecorrespondingtoasequencewithinhumanCENP-A.Accessionno.:P49450,NP_001035891.1HostSpecies:MouseAntibodyClass:IgG1Specificity:ThisantibodyrecognizeshumanCENP-A.Reactivitywithotherspecieshasnotbeeninvestigated.APPLICATIONS
Immunoblotting:useat1ug/ml.Abandof
~18kDaisdetected.
DetectionofCENP-AinlysateofU2OScells
ELISA:useat1-10ug/mlwithCENP-Aonthesolidphase.
Positivecontrol:U2OScelllysate
Thesearerecommendedconcentrations;endusershoulddetermineoptimalconcentrationsfortheirapplications.
DILUTIONINSTRUCTIONS
DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.
STORAGEANDSTABILITY
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.
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