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CatalogNo.:56503

Size:50ugpurifiedbyantigenaffinitychromatographyinPBScontaining0.02%sodiumazide.

TLR3isa904aaproteinwith24N-terminalleucine-richrepeatmotifs(LRRs)andamolecularweightof97kDa.TLR3ismostcloselyrelatedtoTLR5,TLR7,andTLR8,eachwith26%overallsequenceidentity.Invivo,twodifferentsizedtranscriptsforTLR3areobservedsuggestingthatthemRNAisalternativelysplicedtogeneratetwodifferentformsoftheprotein.TLR3mRNAisexpressedathighestlevelsinplacentaandpancreas.ThereareconflictingreportsregardingtheexpressionofTLR3inparticularleukocytepopulations.SomesuggestthatTLR3isonlyexpressedbydendriticcells(DCs),whileothersfindthatTLR3isexpressedbyTorNKcells.WhileitisgenerallyassumedthatTLRsareexpressedonthecellsurface,itnowappearsthatsome,suchasTLR3,maybelocalizedintracellularly,perhapsinthelysosomalcompartment.

Antigen:Syntheticpeptidecorrespondingto15aminoacidsneartheN-terminusofhumanTLR3.

HostSpecies:Rabbit

AntibodyClass:Polyclonal

Preservatives:0.02%sodiumazide

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

ThisantibodyrecognizeshumanandmouseTLR3.

Westernblotting:useat1-2ug/ml.Abandofapproximately97kDaisdetected.

Immunohistochemistry:formalin-fixed,paraffin-embeddedtissues,useat5ug/ml.

Pancreas:Formalin-fixedparaffin-embedded

Placenta:Formalin-fixedparaffin-embedded

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Storeat4oC.Avoidfreezing.

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美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。