PurifiedbyProteinGaffinitychromatography.

SynaptotagminsconstituteafamilyofmembranetraffickingproteinsthatarecharacterizedbyanNterminaltrans-membraneregion(TMR),avariablelinker,andtwoC-terminalC2domains:C2AandC2B.Thereare15membersinthemammaliansynaptotagminfamily.

ThesynaptotagminsareintegralmembraneproteinsofsynapticvesiclesthoughttoactasCa+2sensorsinvesiculartraffickingandexocytosis.

Calciumbindingtosynaptotagmintriggersneurotransmitterreleaseatthesynapse.ThefirstC2domainmediatesCa+2-dependentphospholipidbinding.ThesecondC2domainmediatesinteractionwithStonin2.Synapto-tagmin-6islocalizedtotheendoplasmicreticulumand/orGolgi-likeperinuclearcompartment.Itisalsopresentintheacrosomalregionofmammalianspermatozoa.

Thisantibodyrecognizeshuman,mouseandratSynaptotagmin-6.Itdoesnotcross-reactwithotherSynaptotagmins.

Immunoblotting:useat1ug/ml.Predictedmolecularweightis~55kDa.

Immunoblotonratbrainlysatewith#56532at1ug/ml.

PositiveControl:ratbrainlysate.

Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.

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