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Rab5isamemberoftheRabfamily,Rassuperfamily,ofsmallguanosinetriphosphatases(GTPases)andisexpressedinallhumantissues.RabGTPasesareregulatorsofmembranetraffickingineukaryoticcells.TheirregulatorycapacitydependsontheirABIlitytocyclebetweentheGDP-boundinactiveandGTP-boundactivestates.ActivationofaRabproteiniscoupledtoitsassociationwithintracellularmembranes,allowingittorecruitdownstreameffectorproteinstothecytoplasmicsurfaceofasubcellularcompartment.Throughtheseproteins,RabGTPasesregulatevesicleformation,acitn-andtubulin-dependentvesiclemovementandmembranefusion.Rabaptin-5andEEA1areamongtheproteinsrecruitedbyactiveRab5.

Thisantibodyrecognizeshuman,mouse,rat,bovine,andmonkeyRab5.Otherspecieshavenotbeentested.

Immunoblotting:useat1ug/ml.Abandof~24-26kDaisdetected.

Positivecontrol:HeLacelllysate.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。