productdatasheet

CatalogNo.:2426

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

NuclearfactorkappaB(NF-κB)isaubiquitoustranscriptionfactorandkeymediatorofgeneexpressionduringimmuneandinflammatoryresponses.NF-κBactivatesnumerousgenesinresponsetoextracellularstimuli,suchasIL-1,TNFα,LPS,oxidativestress,andmitogens.NF-κBisassociatedwithIκBincytoplasm.Afterstimulation,1κBisphosphorylatedanddissociatesfromNF-κB.NF-κBenterscellnucleiwhereitactivatesanarrayofgenes.Aserine/threonineproteinkinaseassociatedwithIL-1receptor(IRAK)mediatesasignalingcascadeleADIngto

NF-κBactivation.IRAKisassociatedwithIL-1receptorsubunitsIL-1RIandIL-1RacPandservesasasignalingmoleculetomediateIL-1responses.IRAKalsomediatesIL-18-inducedNF-κBactivation.

Antigen:PeptidecorrespondingtheC-terminusofhumanIRAK.

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

Thisantibodyrecognizesfull-lengthhumanIRAK(80kD).

Immunoblotting:useat1:1,000-1:2,000dilution.

Immunoprecipitation:use2-4ugantibodypersample.

Positivecontrol:WholecelllysatefromHeLacellsorTHP-1cells.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

QEDBioscience,Inc.10919TechnologyPlace,SuiteC

SanDiego,CA92127

TollFree800.929.2114

Phone858.675.2405

Fax858.592.1509

info@qedbio.com

Visitourwebsiteforadditionalproductinformationandtoorderonline.

qedbio.com

美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。