Cav3.1Ca+2ChannelMonoclonalAntibody
IonchannelsareintegralmembraneproteinsthathelpestablishandcontrolthesmallvoltagegrADIentacrosstheplasmamembraneoflivingcellsbyallowingtheflowofionsdowntheirelectRochemicalgradient.Cav3.1isalow-voltage-activatedT-typecalciumchannelexpressedthroughoutthebody.DrugsthatblockT-typecalciumchannelsareusedasantihypertensivesandantiepilepticsandpossIBLyinsomeanestheticsandantipsychotics.
NP_001106284.1).
Thisantibodyrecognizeshuman,mouse,andratCav3.1.Itdoesnotcross-reactwithCav3.2.
Immunoblotting:useat1-2ug/ml.Abandof>200kDaisdetected.
Immunohistochemistry:useat1-10ug/ml.Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.
Positivecontrol:Ratbrainmembranes.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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