Acidsensing(proton-gated)ionchannel1(ASIC1)isacationchannelwithhighaffinityforsodiumwhichisgatedbyextracellularprotonsandinhibitedbythediureticamiloride.ItisalsopermeableforCa(2+),Li(+)andK(+)andmediatesglutamate-independentCa(2+)entryintoneuronsuponacidosis.ThisCa(2+)overloADIngistoxicforcorticalneuronsandmaybeinpartresponsIBLeforischemicbraininjury.ASIC1

functionsasapostsynapticprotonreceptorthatinfluencesintracellularCa(2+)concentrationandcalmodulin-dependentproteinkinaseIIphosphory-lation.

ThisantibodyrecognizesmouseandratASIC1.Itdoesnotcross-reactwithASIC2.

Immunoblotting:useat1ug/ml.Abandof

~60kDaisdetected.

Positivecontrol:Ratbrainlysate.

Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。