CatalogNo.:11137(clonetsp232A)Size:100uginPBS(1mg/ml),pH7.4,50%glycerol,0.09%sodiumazide.

PurifiedbyProteinGaffinitychromatography.

tsp23(transcriptsimilarp23)isahomologofhumanp23,ahighlyconservedubiquitousproteinandacochaperonefortheHsp90chaperonesystem.Asmallprotein(18-25kDa)withasimplestructure,p23isahighlyacidicphosphoproteinwithanasparticacid-richC-terminaldomain.Althoughnumerousstudieshavefoundp23associatedwithotherproteins(i.e,Festyrosinekinase,hemeregulatedkinaseHRI,Hsf1transcriptionfactor,arylhydrocarbonreceptor,telomerase,andHepadnavirusreversetranscriptase),thefunctionalsignificanceofp23remainstobeclearlydefined.ItappearstobeinvolvedinATP-mediatedHsp90bindingofclientproteins.Arecentstudysuggeststhatp23mightbe

apromisingtargetinleukemicapoptosis.tsp23is44%homologouswithp23.

Antigen:Recombinanttsp23HostSpecies:MouseAntibodyClass:IgG1

Thisantibodyrecognizeshumanandmousetsp23.Otherspecieshavenotbeeninvestigated.Itdoesnotcross-reactwithp23.

Immunoblotting:useat1ug/ml.Abandof

~19kDaisdetected.

Immunoblotanalysisofextractspreparedfromindicatedmousetissues(Freemanetal.2000Genes&Dev14:433).

Thesearerecommendedconcentrations;endusershoulddetermineoptimalconcentrationsfortheirapplications.

Positivecontrol:LysateofHeLacellstransientlytransfectedwithTsp23.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.

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