Plasmodiumfalciparumexpressestwoprominentheatshockproteins:heatshockprotein70(PfHsp70)andheatshockprotein90(PfHsp90).Bothoftheseproteinshavebeenimplicatedinthedevelopmentandpathogenesisofmalaria.PfHsp70-1isthemajorcytosolicHsp70inPlasmodiumfalciparum.Itisabundantlyexpressedinthebloodstagesoftheparasiteandappearstoconstituteapprox.1-2%oftotalparasiteprotein.ItisfoundinP.falciparumincomplexeswithPfHsp90andPfHsp40.Thetransitionfromthecoldbloodedmosquitovectortoahostrepresentsphysiologicalstresstotheparasite,and,additionally,malariabloodstageinfectionischaracterizedbyintensefeverperiods.Inrecentyears,ithasbecomeclearthatheatshockproteinsplayanessentialroleduringtheparasite'slifecycle.

Antigen:His-taggedC-terminalaminoacids365-681ofP.falciparumHsp70(Accessionno.M19753).

ThisantibodyrecognizesP.falciparum

Hsp70.

Immunoblotting:useat0.1-1ug/ml.Abandof~70kDaisdetected.

ImmunoblotofPfHsp70in20ugP.falciparum

lysatewith#11147at0.2ug/ml.

Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.

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