Hsp60isanabundant,constitutivelyproducedheatshockproteinthatincreasesincellularconcentrationinresponsetocellshock.Itisfoundinmultiplespeciesandisnotablyhomologousinbacteria,plants,andmammals.Hsp60ofPlasmodiumfalciparumisapolypeptideof577aminoacidswithacalculatedmolecularweightof62158Da.TheprimarystructureofP.falciparumhsp60containsaputativemitochondrialtargetingpeptideatitsamino-terminusandaGGMmotifatitscarboxyl-terminus.Theoverallstructureexhibitsstrongconservation(approximately50%)to

thehsp60fromhumanandothereukaryotes,butonlylowhomology(<30%)toarecentlyreportedP.falciparumchaperonin60gene.TheP.falciparumhsp60geneislocatedonchromosome10.Duringheatshock,the

levelofhsp60transcriptinbloodstageparasitesincreasessignificantlyanditsaccumulationcorrelateswiththedurationoftheinduction.

ThisantibodyrecognizesP.falciparumHsp60andcross-reactswithE.coliHsp60/GroEl.

Immunoblotting:useat1ug/ml.Abandof

~62kDaisdetected.

ImmunoblotofPfHsp60in20ugP.falciparum

lysatewith#11146at1ug/ml.

Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.

美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。