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Hsp90isanabundantlyandubiquitouslyexpressedheatshockproteinfoundinalleukaryoticcells.Itexistsintwoprincipalforms,αandβ,whichshare85%sequencehomology.Bothformsareexpressedinthecytosol.Hsp90αexistsprimarilyasahomodimerwhileHsp90βexistsmainlyasamonomer.

Hsp90playsaroleinfolding,assembly,maturation,andstABIlizationofspecificproteinsasakeycomponentofachaperonecomplex.MostoftheHsp90-regulatedproteinsthathavebeenidentifiedareinvolvedincellsignaling;kinases,v-Src,Wee1,c-Raf,andp53aresomeexamples.WhenboundtoATP,Hsp90interactswithco-chaperonesCdc37,p23,andvariousimmunophilin-likeproteinstoformcomplexesthatstabilizeandprotecttargetproteinsfromproteasomaldegradation.

Antigen:RecombinanthumanHsp90purifiedfromE.coli.

Thisantibodyrecognizeshuman,mouse,andratHsp90αandβ.Otherspecieshavenotbeentested.

Immunoblotting:useat0.5-1ug/ml.Abandof~90kDaisdetected.

ELISA

Immunohistochemistry/Immuno-cytochemistryImunoprecipitation

Usershoulddetermineoptimalconcentrationsfortheirapplication.Positivecontrol:Heat-shockedHeLacelllysate.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

10919TechnologyPlace,SuiteCSanDiego,California92127Tel.(800)929-2114/(858)675-2405Fax(858)592-1509

QEDBioscience,Inc.10919TechnologyPlace,SuiteC

SanDiego,CA92127

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Phone858.675.2405

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info@qedbio.com

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qedbio.com

美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。