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Hsp90isahighlyconservedandessentialstressproteinthatisexpressedinalleukaryoticcells.Itparticipatesinthefolding,assembly,maturation,andstABIlizationofspecificproteinsasanintegralcomponentofchaperonecomplexes.Hsp90isrelativelyabundantinunstressedcellsofmostprokaryoticandeukaryoticsystemsandcanbeinducedbyheatshockinsomesystems.Itexistsinadimericformandhasbeenobservedtobindtoseveralothercellularproteinssuchasretroviruskinases,steroidreceptors,hemeregulatedproteinkinase,actin,andtubulin.WhenboundtoATP,Hsp90interactswithco-chaperonescdc37,p23,andvariousimmunophilin-likeproteins,formingcomplexesthatstabilizeandprotecttargetproteinsfromproteasomaldegradation.

Antigen:Hsp90purifiedfromthewatermoldAchlyaambisexualis.

ThisantibodyisreactivewithboththeconstitutiveandtheinducIBLeformsofhuman,mouse,rat,rabbit,chicken,Sf9cell,Achlya,andwheatgermHsp90.However,itdoesnotbindtothenativeformofHsp90anddoesnotrecognizeE.coliandyeastHsp90.

Immunoblotting:useat1ug/ml.Abandof

~88kDaisdetected.

Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.

Positivecontrol:HeatshockedHeLacelllysate.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。