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Hsp70genes,membersofamultigenefamily,encodeheat-inducIBLe70kDaheat-shockproteinsthatfunctionasmolecularchaperones.Theyhavebeenidentifiedinmostorganellesofeukaryoticcellsaswellasinbacteria.TheN-terminusofHsp70bindsATPwithhighaffinityandtheC-terminusbindsproteinsandpolypeptides.Hsp70sbindnascentpolypeptidesaswellaspartiallyfoldedintermediatesofproteins,thuspreventingtheiraggregationand/ormisfolding.BindingofATPtriggersaconformationalchangethatresultsinthereleaseofboundprotein.Hsp70sfunctioninproteinsynthesis,proteinfoldingandoligomerization,andproteintransport.

ThisantibodyrecognizesinducibleandconstitutiveHsp70/Hsc70ofhuman,mouse,rat,rabbit,monkey,guineapig,hamster,chicken,bovine,canine,ovine,porcine,fish,Xenopus,Drosophila,C.elegans,andplants.Theepitopeisintheregionofaminoacids503-640ofhumanHsp70.

Immunoblotting:useat1ug/ml.Abandof72-73kDaisdetected.

Immunohistochemistry:useat1-10ug/ml.

Immunoprecipitation:1-10ug/ml.

Flowcytometry:useat10ug/ml.

Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.

Positivecontrol:HeLacelllysate.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisantibodyisstableforatleastone(1)yearat4oC.Precipitationmayoccuruponfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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美国QED Bioscience 公司（www.qedbio.com）是专业的抗体公司，有20年的历史，是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司，能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。