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Hippostatin,alsoknownasKLK11,isakallikrein-likeserineprotease,whichhastwoalternativelysplicedisoforms,brain-typeandprostate-type.Hippostatinplaysaroleintheprostate,includingreproductiveand/ortumOrigenicfunctions.ElevatedserumlevelsofKLK11werefoundin70%ofwomenwithovariancancerandin60%ofmenwithprostatecancer.AnalysisoftheKLK11bioMarkerinserummayaidinthediagnosisandmonitoringofovarianandprostaticcarcinoma.
HippostatinconjugatedtoKLHattheC-terminus.
Thisantibodyrecognizeshumanhippostatin/KLK11(35kDa)whichhas86%sequencehomologywithmouseandrat.
Immunoblotting:useat1:500dilution.
Positivecontrol:LNCaPcelllysate
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Diamandis,E.P.etal.(2002)CancerRes.62:295-300.
Nakamura,Tetal.(2003)Prostate54:
299-305.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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美国QED Bioscience 公司(www.qedbio.com)是专业的抗体公司,有20年的历史,是世界著名的抗体生产商。QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司,能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。