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ApoptosisisinducedbycytokinesintheTNFfamilythroughtheirdeathdomaincontainingreceptors.TRICK2(TRAILreceptorinducerofcellkilling2)isamemberoftheTNFreceptorfamilyandcontainstheconserveddeathdomain.TRICK2isexpressedathighlevelsinlymphocytesandspleencellsandinmanytypesoftumorcells.OverexpressionofTRICK2rapidlyinducescelldeathbyapoptosis.TRICK2hasbeenshowntofunctionasareceptorforTRAILandcaninhibitTRAIL-inducedkillingoflymphocyticcells.OthernamesforTRICK2includeDR5,Apo2,TRAIL-R2,andKILLER.
Screaton,GRetal.(1997)CurrBiol7:693-696.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
SPECIFICATIONSUMMARYThisantibodyrecognizeshumanTRICK2.
Immunoblotting:useat1:500dilution.Abandofapproximately57kDaisdetected.
Positivecontrol:wholecelllysatefromHL60,HeLa,orJurkatcells.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
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