Anti-TRICK2(DR5,TRAIL-R2)Antibody
ApoptosisisinducedbycytokinesintheTNFfamilythroughtheirdeathdomaincontainingreceptors.TRICK2(TRAILreceptorinducerofcellkilling2)isamemberoftheTNFreceptorfamilyandcontainstheconserveddeathdomain.TRICK2isexpressedathighlevelsinlymphocytesandspleencellsandinmanytypesoftumorcells.OverexpressionofTRICK2rapidlyinducescelldeathbyapoptosis.TRICK2hasbeenshowntofunctionasareceptorforTRAILandcaninhibitTRAIL-inducedkillingoflymphocyticcells.OthernamesforTRICK2includeDR5,Apo2,TRAIL-R2,andKILLER.
humanTRICK2precursorconjugatedtoKLHattheN-terminus.Thesamesequence
isfoundataminoacids380-398inisoform2.
ThisantibodyrecognizeshumanTRICK2.
Immunoblotting:usea1:500dilution.Abandofapproximately57kDaisdetected.
Positivecontrol:wholecelllysatefromHL60,HeLa,orJurkatcells.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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