CatalogNo.:2430

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.

ApoptosisisinducedbycertaincytokinesincludingTNFandFasligandoftheTNFfamilythroughtheirdeathdomain-containingreceptors,TNFR1andFas.AnovelmemberoftheTNFfamilyhasbeenidentifiedanddesignatedTRAIL(TNF-relatedapoptosis-inducingligand)andApo-2L(Apo-2ligand).TRAILisatypeIImembraneproteinandexpressedinavarietyofhumantissues.Twonoveldeathdomain-containingreceptors,DR4andDR5,havebeenidentifiedasthereceptorforTRAIL.LikeTNFandFasligand,TRAILinducesapoptosisandNF-Bactivationinmanytissuesandcelltypes.

Antigen:Syntheticpeptidecorrespondingtoaa261-277ofhumanTRAIL(accessionno.NP_003801).

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

ThisantibodyrecognizeshumanTRAIL.

Immunoblotting:useat1ug/ml.

WesternblotanalysisofTRAILinHeLacelllysateexpressing10,2.5,or1ngofrecombinantextracellulardomainofTRAILwithTRAILantibodyat1μg/ml.Themwoffull-lengthhumanTRAILis32kDa.

Positivecontrol:HeLacelllysate.

Immunocytochemistry:useat20ug/ml.

ImmunohistochemistryofTRAILinhumanbrainwithTRAILantibodyat20μg/ml.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplication.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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