CatalogNo.:2143

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.

AnovelTNF-R1-interactingproteinhasbeenidentifiedanddesignatedSODD(silencerofdeathdomains).SODDassociateswiththedeathdomainofTNF-R1andpreventsconstitutiveactivationofTNF-R1signaling.TNFtreatmentreleasesSODDandpermitsadaptermoleculessuchasTRADDtoengageintheactiveTNF-R1complex,thusactivatingTNFsignalingpathways.SODDalsointeractswithDR3.

SODDisubiquitouslyexpressedinhumantissuesandcelllines.

Antigen:Syntheticpeptidecorrespondingtoaa2-16ofhumanSODD(accessionno.AF111116).

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

Thisantibodyrecognizeshuman,mouse,andratSODD(60kDa).

Immunoblotting:useat1ug/ml.

WesternblotanalysisofSODDinHeLa(1,3)andTHP-1(2,4)wholecelllysatesintheabsence(1,2)orpresence(3,4)ofblockingpeptidewithSODDantibodyat1g/ml.

Positivecontrol:HeLaorTHP-1celllysate.

Immunocytochemistry:useat5ug/ml

ImmunocytochemicalstainingofSODDinHeLacellswithSODDantibodyat5μg/ml.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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