Anti-LivinAntibody
Apoptosisispreventedbytheinhibitorofapoptosis(IAP)proteins.AnovelmemberintheIAPproteinfamilyhasbeenidentifiedanddesignatedLivinandKIAPforkidneyIAP.Livin/KIAPcontainsasinglebaculoviralIAPrepeat(BIR)domainandaRINGfingerdomainandhastwoisoformstermedLivin-aandLivin-b.TransfectionofLivinincellsresultsinprotectionfromapoptosisinducedbyFADD,BAX,RIP,RIP3andDR6.Livin
hasdirectinteractionwithseveralcaspasesincludingcaspase-3,-7,and-9.Livininhibitstheactivationofcaspase-9inducedbyApaf-1,cytochromec,anddATP.ThetwoisoformsofLivinappeartohavedifferentfunctionsandtissuedistributions.
NP_071444).
ThisantibodyrecognizeshumanLivin(33kDa).
APPLICATIONSImmunoblotting:useat0.5-1.0ug/ml.
WesternblotanalysisofLivinexpressioninhumanRajicelllysatewithLivinantibodyat0.5μg/ml.
Positivecontrol:Rajicelllysate.
Immunohistochemistry:useat5ug/ml.
ImmunohistochemicalstainingofLivininhumansmallintestinewithLivinantibodyat5μg/ml.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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