CatalogNo.:2424

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.

AhumanDNAfragmentationfactor(DFF)thatiscleavedbycaspase-3duringapoptosishasbeenidentified.ThemousehomologueofhumanDFFwasidentifiedasaDNaseinhibitorandwasdesignatedICAD(inhibitorofcaspase-activatedDNase).

UponcleavageofDFF/ICAD,acaspaseactivateddeoxyribonuclease(CAD)isreleasedandactivatedandeventuallycausesthedegradationofDNAinnuclei.Therefore,cleavageofCADinhibitormoleculeDFF/ICAD,whichcausesDNaseactivationandDNAdegradation,isahallmarkofapoptoticcelldeath.

Antigen:Peptidecorrespondingtoaa312-331attheC-terminusofmouseICAD(accessionno.O54786).

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

Thisantibodyrecognizesnon-cleaved(45kDa)andcleavedmouseICAD.

Immunoblotting:useat1ug/ml.

WesternblotanalysisofICADinmurinelung(L),brain(B),liver(L),andkidneytissuelysatewithanti-ICAD(CT)at1ug/ml.

Positivecontrol:Mouselungtissuelysate.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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