CatalogNo.:2289

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.

AnovelBH3domain-containingproteinwasrecentlyidentifiedanddesignatedBnip3L,Bnip3,orNix.Bnip3LisahomologoftheE1B19K/Bcl-2bindingandpro-apoptoticproteinBnip3.OverexpressionofBnip3Linducesapoptosis.Bnip3LinteractswithandovercomessuppressionbyBcl-2andBcl-xL.Bnip3Lislocalizedinmitochondria.ThemessengerRNAofBnip3Lisubiquitouslyexpressedinhumantissues.

Bnip3LandBnip3formanewsubfamilyofthepro-apoptotic-mitochondrialproteins.

Antigen:Peptidecorrespondingtoaa77-92ofhumanBnip3L(accessionno.

AF067396)Thisaminoacidsequenceisidenticaltothatofmouse.

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

ThisantibodyrecognizesmonomerichumanandmouseBnip3L.Abandof40kDaisdetectedinimmunoblots.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

Immunoblotting:useat1ug/ml.

WesternblotanalysisofBnip3LinK562wholecelllysateintheabsence(A),orpresence(B)ofimmunogenicpeptidewithBnip3Lantibodyat1μg/ml.

Immunohistochemistry:useat2ug/ml.

ImmunohistochemicalstainingofhumankidneytissueusingBnip3Lantibodyat2μg/ml.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

Positivecontrol:WholecelllysateofhumanK562cells.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

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