Anti-Bcl-3MonoclonalAntibody
ThegeneencodingBcl-3wasfirstidentifiedasthegenealteredinsomecasesofchronicBcelllymphocyticleukemiaandwaslaterfoundtobelongtotheIκBsubfamilyofinhibitorsofNFκBtranscriptionfactors.Bcl-3doesnothaveDNA-bindingactivity,butitinteractswithNFκB1andNFκB2which,whenboundtoDNA,repressgenetranscription.Therefore,Bcl-3maypromotegeneexpressionthatisrepressedbymembersoftheNFκBfamily.Bcl-3RNAishighlyexpressedinspleenandliverwithlowerlevelsofexpressioninheart,skeletalmuscle,lung,kidney,andtestes.
ThisantibodyrecognizeshumanandmouseBcl-3.
Immunoblotting:useat2ug/ml.Abandofapprox.64kDaisdetected.
ELISA:Endusershoulddetermineoptimalconcentrationforeachsample.
Positivecontrol:JurkatTcelllysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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